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. 2013 Dec 4;111(4):836–848. doi: 10.1152/jn.00382.2013

Fig. 3.

Fig. 3.

Contribution of FSI-MSN and MSN-MSN synapses to striatal balance. A: removing FSI inhibition (F) to MSNs introduces a 40% imbalance in firing between D1 and D2 MSNs. B: removing MSN-MSN synapses (M) and replacing those GABAergic synapses with extrinsic input trains (Ext) that keep the overall inhibition similar to control (CNTL) level results in a large increase in firing frequency, but only 18% difference between D1 and D2 MSN firing frequencies. C: reducing the weight (dashed lines) of FSI-MSN synapses to the level of MSN-MSN synapses (8.4 nS to 0.75 nS) produced slight changes (9%) to firing differences between D1 and D2 MSNs. D: removing proximal FSI-MSN synapses and making FSI-MSN synapses as distal as MSN-MSN synapses also did not disrupt balance of firing. E: a delay of 65 ms was added to FSI-MSN synaptic connections to identify the contribution of early FSI firing on disrupting balance in firing. This resulted in a 10% difference in firing between the MSN classes. All percent differences are calculated as difference divided by mean. F: table of mean firing frequencies and %differences between D1 and D2 MSNs for the CNTL condition and for the conditions are represented by the respective panels.