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. 2013 Dec 4;111(4):836–848. doi: 10.1152/jn.00382.2013

Fig. 5.

Fig. 5.

Effects of modulating channel properties and their interaction with inhibitory input on affecting striatal balance. A: equalizing L-type calcium channels (CaL), fast-sodium channel (NaF), KAs, or KIR produces imbalance between D1 and D2 MSN firing (P < 0.01 for all conditions). B: when CaL or KAs/KIR (data not shown) conductances are equalized between D1 and D2 MSNs, removing FSIs or GJs does not affect the imbalance in firing. When NaF properties are equalized, removing GJs no longer produces the significant difference in firing between the two MSN classes, restoring balance in firing between D1 and D2 MSNs.