Fig. 4.
High-frequency stimulation evokes glycinergic synaptic transmission in NM and NL. A: traces from an NM neuron show spontaneous inhibitory postsynaptic currents (IPSCs) that are completely abolished during SR95531 application, suggesting purely GABAergic events (n = 4, population data not shown). B: overlay of averaged inhibitory postsynaptic potentials (IPSPs) evoked during single-pulse stimulation (arrowhead) confirm purely GABAergic events in NM (n = 3). C: averaged IPSC traces evoked with a 200-Hz, 50-pulse stimulus (dashed line) in each pharmacological condition in an NM neuron. GABAAR block reduces the summed IPSC amplitude, leaving a gradually increasing component (arrow) that is eliminated by strychnine application. D: averaged IPSC traces from 200-Hz stimulus train in the NL show similar trend during pharmacological manipulations. Color code in C for pharmacological condition is the same for A–D.