Sfpq knockdown enhances visual recovery and regeneration-associated gene expression after optic nerve lesion. A, Diagram of optokinetic apparatus. Fish received bilateral optic nerve lesions and control or sfpq MO was applied to both the left and right optic nerve stumps overnight. B, Quantification of eye saccades tracking visual stimulus in sham, control, or sfpq MO-treated fish. *p < 0.05, compared with control MO. **p < 0.01, compared with control MO. n = 6. Error bars indicate SD. C, Diagram of the apparatus used to measure the escape response to a phantom prey. D, Quantification of escape response. *p < 0.05, compared with control MO. **p < 0.01, compared with control MO. n = 4. Error bars indicate SD. E, qPCR analysis of the effects of control or sfpq MO on expression of genes associated with regeneration. *p < 0.05, compared with control MO. **p < 0.01, compared with control MO. n = 3. Error bars indicate SD.