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. 2014 Feb 12;34(7):2632–2644. doi: 10.1523/JNEUROSCI.3898-13.2014

Figure 6.

Figure 6.

Optic axon regeneration is mediated by a Jak/Stat3 signaling cascade. A, Immunofluorescence detection of p-Stat3 (green) in RGCs (arrows) during optic nerve regeneration is enhanced by Socs3a knockdown. Nuclei are stained with DAPI (blue). Scale bar, 20 μm. B, Axon outgrowth from retinal explants is inhibited by the Jak/Stat signaling inhibitor, JSI 124. Scale bar, 500 μm. C, Quantification of axon density and length for control, JSI-124-, and P6-treated retinal explants. ***p < 0.001, compared with the DMSO-treated controls. n = 4. Error bars indicate SD. D, Jak/Stat inhibitors JSI-124 and P6 inhibit injury-dependent induction of socs3a and sfpq mRNAs. *p < 0.05, compared with DMSO controls. **p < 0.01, compared with DMSO controls. ***p < 0.001, compared with DMSO controls. n = 4. Error bars indicate SD. INL, Inner nuclear layer; GCL, ganglion cell layer.