Figure 1.

Conditional deletion of Mecp2 with Emx1-Cre leads to spike-wave discharges. A, Seizure activity in an Emx1-Mecp2 mutant mouse at 7 weeks of age. EEG was recorded from a wake Emx1-Mecp2 mouse using four electrodes placed over the right frontal (RF), left frontal (LF), right back (RB), and left back (LB) surface of the neocortex. Each trace is the differential between signals recorded from two of the electrodes. B, EEG recording from a control mouse (Mecp2^wt/y; Emx1-Cre) at 7 weeks of age. C, EEG recording from a Dlx6a-Mecp2 mutant mouse at 7 weeks of age.