Table 1.

F-AD Cases; Reports and Denial of Lesions

Year	Event	Location
1887*	Observation of cortical plaques (4)	Russia [47]
1892	Observation of plaques and tangles (1)	France [48]
1898	Ditto (2)	Vienna [16]
1900	Existence of miliary scleroses  (plaques) denied	Scotland [35]
1901	Fischer diagnoses Frau Josefa V	Prague [3, 9]
	Alzheimer diagnoses Frau Auguste D	Frankfurt [4, 7, 8]
	Observation of plaques (1)	Leipzig [49]
1903	Death of Frau V	Prague [3, 9]
1906	Observation of plaques and tangles (1)	France [50]
	Observation of plaques (2)	Tokyo [51]
	Death of Frau D	Frankfurt [4, 6-8]
	Alzheimer describes lesions in Frau D (1)	TÜbingen [4, 6-8]
1907	Observation of plaques and tangles in Frau V and others  (12)	Prague [3]
	Alzheimer publishes findings on lesions in Frau D	Frankfurt [4]
1908	Observation of plaques and tangles (1)	Munich [52]
1909	Ditto (6)	Frankfurt, Freiburg [53]
1910	Ditto (44)	Prague [5, 9]
	Ditto (2)**	Munich [6]
	Ditto (8)	Michigan [54]
1911	Ditto (1)	Washington [55]
	Ditto (24)	Munich [56]
	Ditto (16)	Massachusetts [57]
1971	High PN usage linked with nephrotoxicity, dementia, and F-AD lesions (6)	Glasgow [24]
2001	PA implicated as a cause of F-AD	London [27]

Numbers of subjects with lesions are given in parentheses.

^*The results were communicated orally in 1886.

^**Two single cases were described elsewhere [4, 52].