Figure 4.

Normal D1-like dopamine receptor agonist induced locomotor activity, but impaired MK801-elicited hyperlocomotion in GR^D1Cre mice. Locomotor responses are presented as ¼ turn per 5 min. (A) Locomotor response to saline and SKF81297 1.5 mg/kg (left panel) and 3 mg/kg (right panel) in control and GR^D1Cre mice. Interaction Drug × Time for SKF81297 at 1.5 mg/kg [F_{(17, 714)} = 10.3, P < 0.001] and 3 mg/kg [F_{(17, 714)} = 9.4, P < 0.001], but no interaction Drug × Time × Genotype, F_{(17, 714)} = 1.2, P > 0.05 and F_{(17, 714)} = 0.8, P > 0.05, respectively. (B) MK801 elicited a stronger hyperlocomotion in control than GR^D1Cre mice, interaction Drug × Time × Genotype, F_{(18, 756)} = 1.9, P < 0.01. °°P < 0.01, control vs. mutant. n = 8–14 mice per group.