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. 2014 Feb 12;6:2. doi: 10.3389/fnsyn.2014.00002

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Copyright © 2014 Choi, Yu, Rabello, Merlo, Zemmar, Walton, Moreno, Moreira, Sugimori and Llinás.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High frequency stimulation in Control and RNS60 ASW. (A) Presynaptic (red) and Postsynaptic (black) spikes generated by a repetitive presynaptic electrical stimulation at 200 Hz. (B) Failure of all postsynaptic spike generation after 100 consecutive trains repeated at 1 Hz in Control ASW. (C) Same as in (B) recorded in RNS60 ASW. (D) Partial recovery of postsynaptic spike generation after a 30 s rest period in control ASW. (E) Partial recovery after rest period in RNS60 ASW. Note in (D,E) that in the presence of RNS60 ASW there was a more vigorous recovery of postsynaptic spike generation after a similar 30 s rest period than in control ASW. Similar results were obtained in four other synapses utilizing the same stimulus paradigm.