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. 2014 Feb 12;6:2. doi: 10.3389/fnsyn.2014.00002

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Copyright © 2014 Choi, Yu, Rabello, Merlo, Zemmar, Walton, Moreno, Moreira, Sugimori and Llinás.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synaptic noise recorded in Control ASW and RNS60 ASW. (A) Recordings showing synaptic noise across the postsynaptic membrane superfused with control ASW (green) and the increase in noise amplitude 5 min (red) and 10 min (blue) after superfusion with RNS60 ASW as well as the background extracellular noise recorded directly from the bath (black). (B) Plot of change in noise amplitude as a function of time after superfusion with RNS60 ASW in four synapses. (C) Plot of noise amplitude as a function of frequency (note log scale) in control ASW (red) and 10 min after superfusion with RNS60 ASW (black). The insert shows modeled results indicating that the change in noise could be interpreted as a change in the time course and amplitude of synaptic noise (for details see Lin et al., 1990).