Table 1. The Rab proteins: involved autophagy stage, related effector proteins in autophagy, and physiological role in membrane traffic.
| Involved autophagy stage | Rab protein | Related effectors | Membrane traffic pathway/function | References |
|---|---|---|---|---|
| Autophagosome formation | Rab1 | Atg9, Bacterial proteins (VirA, DrrA, LidA, and LepB) | ER to Golgi | 30, 45, 48, 54, 55 |
| Rab5 | p110β, Beclin1, Vps34, and HCV protein NS4B | Early endosome fusion | 30, 57, 58, 60 | |
| Rab7 | Unknown | Late endosome to lysosome | 30, 64 | |
| Rab9A | Raclopride | Endosome to TGN | 30, 66, 76 | |
| Rab11 | TBC1D14 | TGN/RE to plasma membrane | 30, 69, 71 | |
| Rab23 | Unknown | Protein recycling/transport to plasma membrane | 30, 66 | |
| Rab32 | Claret | TGN to melanosome, mitochondrial fission | 30, 72, 73 | |
| Rab33B | Atg16L | Only functions in autophagy | 30, 74 | |
| Autophagosome maturation | Rab7 | FYCO1, RILP, and Csn8 | Late endosome to lysosome | 30, 77, 78, 79, 80, 81, 82, 84, 90 |
| Rab8B | TBK-1 | Exocytosis, TGN/RE to plas- ma membrane | 30, 92 | |
| Rab24 | Drs | Chromosome segregation, and cytokinesis in normal cell division | 30, 95, 96, 98 | |
| Unknown | Rab7 | Curcumin | Late endosome to lysosome | 30, 100 |
| Rab8A | Unknown | Exocytosis, TGN/RE to plas- ma membrane | 30, 101 | |
| Rab25 | Unknown | RE (apical) to plasma membrane | 30, 109 |
Abbreviations: ER, endoplasmic reticulum; HCV, hepatitis C virus; RE, recycling endosome; RILP, Rab7-interacting lysosomal protein; TBK, TANK-binding kinase 1; TGN, trans-Golgi network