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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: Soft Matter. 2013 Feb 28;9(8):2467–2474. doi: 10.1039/C2SM27567H

Fig. 5.

Fig. 5

Effects of Rho family GTPases on directional cell migration within teardrop gelatin microchannels. (A) Time-lapse images (in hours) show the movement of NIH3T3 fibroblast mutants with constitutively activated RhoA, Rac1, and Cdc42 in 60°, 90°, 120° and 180° microchannels. Scale bars: 100 μm. (B) Directional ratio and net translocation of cell migration. Graphs show the movement of wild type (WT) and NIH3T3 fibroblast mutants with constitutively activated RhoA, Rac1, and Cdc42. Data collected from >150 analyzed turns and >50 cells. Error bars are mean ± S.E.