Table 5.

Genotypes and allele frequencies of the A148T allele in different populations

	Geographic origin	Study population	Genotype	Frequency of A148T gene CDKN2A polymorphism	Reference
1.	North-Western Italy	Melanoma families n = 14	–	5/14 (35.7%)	Chiorzo et al. (1999) [22]
2.	French and Italian population	Italian melanoma patients n = 119 Italian controls n = 121 French melanoma patients n = 500 French controls n = 143	A/A G/A G/G A/A G/A G/G A/A G/A G/G A/A G/A G/G	6.72% 1 (0.84%) 14 (11.76%) 104 (87.40%) 6.2% 1 (0.83%) 13(10.74%) 107 (88.43%) 3.4% 1 (0.2%) 32 (6.4%) 467 (93.4%) 4.2% 0 (0.0%) 12 (8.4%) 131 (91.6%)	Spica et al. (2006) [24]
3.	UK	Atypical nevus/Familial melanoma n = 488 Population-based sample n = 599	A/A G/A G/G A/A G/A G/G	0/488 (0.0%) 24/488 (4.9%) 464/488 (93.0%) 0/599 (0.0%) 31/599 (5.2%) 568/599 (94.8%)	Bertram et al. (2002) [23]
4.	Sweden	Hereditary melanoma n = 108	–	9.3% in patients sample	Erlandson et al. (2007) [25]
5.	Spain	Patients with more than one primary cutaneous melanoma n = 104 Spanish controls n = 110	–	13.40% 5.45%	Puig et al. (2005) [26]
6.	Spain	Breast cancer and cutaneous melanoma n = 31	–	2/31 (6.4%)	Nagore et al. (2009) [27]
7.	Poland	Larynx cancer n = 390	–	17/390 (4.4%)	Kiwerska et al. (2007) [28]
8.	Sweden (Stockholm County)	Bladder cancer n = 167	–	10/167 (6%)	Sakano et al. (2003) [29]