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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: DNA Repair (Amst). 2013 Nov 11;12(12):1114–1121. doi: 10.1016/j.dnarep.2013.10.008

Fig. 2. SAHA inhibits HR repair and synergistically enhances GCV cytotoxicity in HR proficient cells.

Fig. 2

A, HeLa-D-GFP-TK cells were incubated with SAHA alone or with the AdNGUS24i adenovirus containing the cDNA for the I-SceI endonuclease. After 48 hr, cells were assessed for GFP expression by flow cytometry. Bars represent a mean of at least three experiments performed in triplicate ± SEM. *, GFP not detectable. B, Cytotoxicity of SAHA and GCV in U251tk glioblastoma cells. C, Synergy with GCV and SAHA identified by isobologram analysis; diagonal line, isoeffective line of additivity.

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