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. Author manuscript; available in PMC: 2014 Feb 12.
Published in final edited form as: Nat Neurosci. 2009 Sep 6;12(10):1285–1292. doi: 10.1038/nn.2394

Fig. 2.

Fig. 2

EphrinA3 is required for TBS-induced LTP. a, fEPSPs slopes at various stimulus intensities (FV, fiber volley) and representative traces (+/+, black; ephrinA3, gray, n=12 slices, 6 mice per group, ANCOVA, p=0.1). b, PPF at various ISIs and representative traces at 40 ms ISI (+/+, black; ephrinA3, gray, n=10 slices, 5 mice per group, two-way repeated measures ANOVA, between genotypes: F(1, 90)=0.03, p=0.9). c–f, Scatter plots showing LTP induced by stimulation of presynaptic CA3 neurons with three TBS (c) or a single tetanus (d–f). c, ephrinA3−/− mice show a strong deficit in TBS-induced LTP compared to +/+ controls (+/+, 140.7 ± 6.1%, n=14 slices, 10 mice; ephrinA3−/−, 114.8 ± 5.0% n=12 slices, 10 mice, at 55–60 min after stimulus, t-test, p=0.004). d, ephrinA3−/− mice show normal tetanus-induced LTP (+/+, 138.6 ± 6.0%, n=13 slices, 10 mice; ephrinA3−/−, 137.9 ± 7.7% n=12 slices, 10 mice, at 55–60 min after stimulus, t-test, p=0.9). e, CA1-Cre;EphA4lx/− mice show normal tetanus-induced LTP (142.8 ± 6.0% in mutants, n=11 slices, 9 mice, versus 151.0 ± 11.0% in controls, n=12 slices, 9 mice, at 55–60 min after stimulus, t-test, p=0.5). f, CA3-Cre;EphA4lx/− mice have normal tetanus-induced LTP (133.8 ± 7.9% in mutants, n=10 slices, 8 mice, versus 134.0 ± 5.4% in controls, n=9 slices, 8 mice, at 55–60 min after stimulus, t-test, p=1.0). Insets: representative traces from controls (black) and mutants (gray) recorded before (stars) and 55–60 min after (triangles) LTP induction. The stimulation artifacts were removed. Error bars: s.e.m.