Table 1. Summary of maximum toxicities related to anti-OX40 at all dose levels.
Adverse events | ||||
---|---|---|---|---|
Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
Lymphopenia | 3 | 10 | 6 | 1 |
Fatigue | 7 | 12 | ||
Rash/Skin Changes | 4 | 6 | ||
Pruritis | 5 | 1 | ||
Fever/Chills | 11 | 2 | ||
Splenomegaly | 7 | |||
Arthralgias/Myalgias | 5 | 5 | ||
Nausea/Vomiting | 4 | 3 | ||
Increased AST, ALT or alkaline phosphatase | 2 | 1 | ||
Anemia | 1 | 8 |