Table 3.
GO-analysis of 44 signature genes
| Biological process GO ID | P-value | Odds ratio | Ex-pected | Count | Size | GO Term | Associated gene symbols |
|---|---|---|---|---|---|---|---|
| GO:0006955 |
1.4E-12 |
31.69 |
1.04 |
13 |
620 |
Immune response |
HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, CCL18, CXCL11, BNIP3, CD86, CD74 |
| GO:0002376 |
4.6E-12 |
26.94 |
1.47 |
14 |
874 |
Immune system process |
HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74 |
| GO:0002504 |
1.8E-08 |
208.89 |
0.03 |
4 |
18 |
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5 |
| GO:0019882 |
3.5E-08 |
73.05 |
0.10 |
5 |
58 |
Antigen processing and presentation |
HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, CD74 |
| GO:0050896 |
3.6E-06 |
8.20 |
4.13 |
14 |
2454 |
Response to stimulus |
HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74 |
| GO:0002828 |
4.0E-05 |
327.34 |
0.01 |
2 |
6 |
Regulation of T-helper 2 type immune response |
IDO1, CD86 |
| GO:0002682 |
6.7E-05 |
14.53 |
0.45 |
5 |
267 |
Regulation of immune system process |
HLA-DMA, IDO1, ORM1, CD86, CD74 |
| GO:0042092 |
1.2E-04 |
163.62 |
0.02 |
2 |
10 |
T-helper 2 type immune response |
IDO1, CD86 |
| GO:0006954 |
1.4E-04 |
12.44 |
0.52 |
5 |
310 |
Inflammatory response |
IDO1, CXCL9, ORM1, CCL18, CXCL11 |
| GO:0030217 |
1.5E-04 |
34.98 |
0.10 |
3 |
62 |
T cell differentiation |
HLA-DMA, CD86, CD74 |
| GO:0045058 |
1.8E-04 |
130.87 |
0.02 |
2 |
12 |
T cell selection |
HLA-DMA, CD74 |
| GO:0006952 |
2.2E-04 |
8.75 |
0.93 |
6 |
550 |
Defense response |
IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3 |
| GO:0045582 |
3.2E-04 |
93.45 |
0.03 |
2 |
16 |
Positive regulation of T cell differentiation |
HLA-DMA, CD86 |
| GO:0045621 |
4.1E-04 |
81.76 |
0.03 |
2 |
18 |
Positive regulation of lymphocyte differentiation |
HLA-DMA, CD86 |
| GO:0002460 |
4.7E-04 |
23.13 |
0.16 |
3 |
92 |
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
HLA-DMA, IDO1, CD86 |
| GO:0030098 |
4.7E-04 |
23.13 |
0.16 |
3 |
92 |
Lymphocyte differentiation |
HLA-DMA, CD86, CD74 |
| GO:0002250 |
4.9E-04 |
22.88 |
0.16 |
3 |
93 |
Adaptive immune response |
HLA-DMA, IDO1, CD86 |
| GO:0044419 |
5.8E-04 |
12.38 |
0.40 |
4 |
236 |
Interspecies interaction between organisms |
HLA-DRB4, MMP1, BNIP3, CD86 |
| GO:0009611 |
7.2E-04 |
8.52 |
0.75 |
5 |
445 |
Response to wounding |
IDO1, CXCL9, ORM1, CCL18, CXCL11 |
| GO:0002694 |
8.8E-04 |
18.52 |
0.19 |
3 |
114 |
Regulation of leukocyte activation |
HLA-DMA, CD86, CD74 |
| GO:0050865 |
1.0E-03 |
17.56 |
0.20 |
3 |
120 |
Regulation of cell activation |
HLA-DMA, CD86, CD74 |
| GO:0045580 |
1.1E-03 |
46.67 |
0.05 |
2 |
30 |
Regulation of T cell differentiation |
HLA-DMA, CD86 |
| GO:0051704 |
1.2E-03 |
7.57 |
0.84 |
5 |
498 |
Multi-organism process |
HLA-DRB4, IDO1, MMP1, BNIP3, CD86 |
| GO:0042110 |
1.4E-03 |
15.54 |
0.23 |
3 |
135 |
T cell activation |
HLA-DMA, CD86, CD74 |
| GO:0050776 |
1.7E-03 |
14.54 |
0.24 |
3 |
144 |
Regulation of immune response |
HLA-DMA, IDO1, CD86 |
| GO:0002822 |
1.8E-03 |
36.28 |
0.06 |
2 |
38 |
Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
IDO1, CD86 |
| GO:0045619 |
1.8E-03 |
36.28 |
0.06 |
2 |
38 |
Regulation of lymphocyte differentiation |
HLA-DMA, CD86 |
| GO:0002819 |
1.9E-03 |
35.29 |
0.07 |
2 |
39 |
Regulation of adaptive immune response |
IDO1, CD86 |
| GO:0002521 |
1.9E-03 |
13.94 |
0.25 |
3 |
150 |
Leukocyte differentiation |
HLA-DMA, CD86, CD74 |
| GO:0002684 |
1.9E-03 |
13.94 |
0.25 |
3 |
150 |
Positive regulation of immune system process |
HLA-DMA, IDO1, CD86 |
| GO:0006935 |
2.1E-03 |
13.57 |
0.26 |
3 |
154 |
Chemotaxis |
CXCL9, CCL18, CXCL11 |
| GO:0042330 |
2.1E-03 |
13.57 |
0.26 |
3 |
154 |
Taxis |
CXCL9, CCL18, CXCL11 |
| GO:0007267 |
2.3E-03 |
6.50 |
0.97 |
5 |
576 |
Cell-cell signaling |
CXCL9, PCSK1, CCL18, CXCL11, CD86 |
| GO:0050870 |
3.5E-03 |
25.58 |
0.09 |
2 |
53 |
Positive regulation of T cell activation |
HLA-DMA, CD86 |
| GO:0046649 |
4.2E-03 |
10.52 |
0.33 |
3 |
197 |
Lymphocyte activation |
HLA-DMA, CD86, CD74 |
| GO:0051251 |
5.0E-03 |
21.37 |
0.11 |
2 |
63 |
Positive regulation of lymphocyte activation |
HLA-DMA, CD86 |
| GO:0007626 |
5.5E-03 |
9.52 |
0.37 |
3 |
217 |
Locomotory behavior |
CXCL9, CCL18, CXCL11 |
| GO:0009605 |
5.6E-03 |
5.20 |
1.20 |
5 |
710 |
Response to external stimulus |
IDO1, CXCL9, ORM1, CCL18, CXCL11 |
| GO:0030097 |
5.6E-03 |
9.43 |
0.37 |
3 |
219 |
Hemopoiesis |
HLA-DMA, CD86, CD74 |
| GO:0002696 |
6.3E-03 |
18.88 |
0.12 |
2 |
71 |
Positive regulation of leukocyte activation |
HLA-DMA, CD86 |
| GO:0050867 |
6.6E-03 |
18.34 |
0.12 |
2 |
73 |
Positive regulation of cell activation |
HLA-DMA, CD86 |
| GO:0045321 |
6.8E-03 |
8.77 |
0.40 |
3 |
235 |
Leukocyte activation |
HLA-DMA, CD86, CD74 |
| GO:0048534 |
7.1E-03 |
8.66 |
0.40 |
3 |
238 |
Hemopoietic or lymphoid organ development |
HLA-DMA, CD86, CD74 |
| GO:0048583 |
7.2E-03 |
8.62 |
0.40 |
3 |
239 |
Regulation of response to stimulus |
HLA-DMA, IDO1, CD86 |
| GO:0050863 |
8.1E-03 |
16.47 |
0.14 |
2 |
81 |
Regulation of T cell activation |
HLA-DMA, CD86 |
| GO:0002520 | 8.4E-03 | 8.13 | 0.43 | 3 | 253 | Immune system development | HLA-DMA, CD86, CD74 |