Table 2.

Functional classification of identified intracellular proteins from voriconazole susceptible, susceptible dose-dependent, and resistant strains

Protein	Function
Cell regulation
Similar with bacterial potassium efflux protein KefA	Regulate iron balance
Sphingolipid long chain base sensory protein	Cell wall, antifungal protection
Heat shock protein 70, 90, 60	Stress, protein folding
SES1 seryl-transcription RNA (tRNA) synthetase	Catalyze the formation of aminoacyl-tRNA
GDP dissociation inhibitor	GTP binding protein regulator
similar to Saccharomyces cerevisiae YKL195w	Promotes retention of newly imported proteins
Chromosome segregation adenosine triphosphatases (ATPases)	Cell division
Highly similar to S. cerevisiae YGR086c	Unknown function that are induced on cell stress
CAP family of transcription factors	Control transcription of genes
Carbohydrate transport and metabolism
Pyruvate decarboxylase	Related thiamine pyrophosphate-requiring enzymes
Hexokinase	Phosphorylates a six-carbon sugar, a hexose to a hexose phosphate
Amino acid transport and metabolism
SAM1 S-adenosylmethionine synthetase	Catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine
Energy production and conversion
F1 ATP synthase	Catalyze the ATP synthesis
Phosphoglycerate kinase	Catalyzes the transfer of the high-energy phosphate group of 1,3-biphosphoglycerate to adenosine diphosphate