Table 4.
Functional classification of identified membrane proteins from voriconazole susceptible, susceptible dose-dependent, and resistant strains
| Protein | Function |
|---|---|
| Cell regulation | |
| Similar with bacterial potassium efflux protein KefA | Regulate iron balance |
| Sphingolipid long-chain base sensory protein | Cell wall, antifungal protection |
| Heat shock protein 70, 90, 60 | Stress, protein folding |
| SES1 seryl-transcription RNA (tRNA) synthetase | Catalyze the formation of aminoacyl-tRNA |
| GDP dissociation inhibitor | GTP binding protein regulator |
| similar to Saccharomyces cerevisiae YKL195w | promotes retention of newly imported proteins |
| Chromosome segregation adenosine triphosphatases (ATPases) | Cell division |
| highly similar to Saccharomyces cerevisiaeYGR086c | Unknown function that are induced on cell stress |
| Cu, Zn enzyme superoxide dismutase | Catalyse the conversion of superoxide radicals to oxygen |
| CAP family of transcription factors | Control transcription of genes |
| Molecular chaperone DnaK | Posttranslational modification, protein turnover, chaperones |
| Carbohydrate transport and metabolism | |
| Pyruvate decarboxylase | Related thiamine pyrophosphate-requiring enzymes |
| Hexokinase | Phosphorylates a six-carbon sugar, a hexose to a hexose phosphate |
| Amino acid transport and metabolism | |
| SAM1 S-adenosylmethionine synthetase | Catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine |
| Elongation factor 1 beta (EF1B) | catalyzes the exchange of GDP bound to the G-protein, EF1A, for GTP |
| Energy production and conversion | |
| F1 ATP synthase | Catalyze the ATP synthesis |
| Phosphoglycerate kinase | catalyzes the transfer of the high-energy phosphate group of 1,3-biphosphoglycerate to adenosine diphosphate |