Table I.

Summary of angiogenesis-related genes differentially expressed in leiomyoma relative to myometrium in microarray studies.

Angiogenic factor	Gene symbol	Tsibris et al. (2002)	Chegini et al. (2003b)	Wang et al. (2003)	Weston et al. (2003)	Ahn et al. (2003)	Catherino et al. (2004)	Quade et al. (2004)	Hoffman et al. (2004)	Arslan et al. (2005)	Ishikawa et al. (2007)	Tsiligiannis et al. (2013)
EGF	EGF											↑
HB-EGF	HBEGF			↓
VEGF	VEGF		↓						↓		↓
aFGF	FGFI											↑
PDGF	PDGFA											↑
	PDGFB										↓
	PDGFC								↑
TGF-β	TGFB1								↑
	TGFB2											↑
	TGFB3	↑					↑	↑			↑
CTGF	CTGF				↓	↓		↓	↓	↓
CYR61	CYR61	↓			↓	↓		↓	↓	↓	↓
Col4α2	COL4A2				↑	↑
HIF-1α	HIF1A		↓									↑
EGR-1	EGR1		↓						↓		↓

↑ or ↓denote increased or decreased expression, respectively, in leiomyoma compared with myometrium. EGF, epidermal growth factor; HB-EGF, heparin-binding EGF; VEGF, vascular endothelial growth factor; aFGF, acidic fibroblast growth factor; PDGF, platelet-derived growth factor; TGF-β, transforming growth factor-β; CTGF, connective tissue growth factor; CYR61, cysteine-rich angiogenic inducer 61; Col4α2, collagen 4α2; HIF-1α, hypoxia-inducible factor-1α; EGR-1, early growth response-1.