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. 2013 Nov 13;69(3):651–663. doi: 10.1093/jac/dkt442

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© The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Expression of TbAQP2 in multidrug-resistant trypanosomes sensitizes to (a) pentamidine and (b) Cymelarsan but not (c) diminazene or (d) phenylarsine oxide. EC₅₀ values were obtained using the Alamar blue assay and bars represent the mean and SEM of 3 to >10 independent determinations; data were analysed for significant differences from the wild-type control using one-way ANOVA/Tukey's test (GraphPad Prism 5.0). NS, not significant; *P < 0.05; **P < 0.01; ***P < 0.001; unless otherwise indicated, relative to wild-type controls. EV, empty-vector control.