Understanding disparities in subpopulations of women who smoke

Abstract

Tobacco use is the leading known cause of preventable death and disease among women. In this paper we use fundamental concepts and definitions from the general health-disparities literature to examine smoking behavior among subpopulations of women. We focus on three factors associated with disparities in smoking behavior among subgroups of women—race and/or ethnicity, educational status, and acculturation. We suggest that research on smoking behavior among subpopulations of women is beginning to reveal not only different smoking behavior but disparities among women in different subpopulations. We conclude that subpopulation-based understanding of gender differences and disparities in smoking is critical to improvement of research design, intervention objectives, and public health policy on smoking in women.

Introduction

Smoking is the single most costly health-risk behavior and the leading cause of preventable death in the United States; examination of current smoking habits shows that approximately 17 % of women and 22 % of men in the US smoke [1]. Smoking-cessation intervention is a critical component of tobacco-control policies, and evidence-based studies indicate it is beneficial to smokers [2, 3]. Successful programs that target reduction of smoking are predicated on using an understanding of the different smoking behavior among subpopulations of smokers to develop and provide intervention designed for effective treatment.

For example, studies based on samples of treatment-seeking women and men find that the same proportion of women and men attempt to quit [4], and that women use even more quit strategies during an attempt than men [4] yet have greater difficulty achieving and sustaining abstinence from smoking when quitting on their own, or using first-line treatment (for example nicotine replacement therapy or pharmacologic and behavioral treatment) [5, 6]. Moreover, smoking reduction requires an understanding of whether and how subpopulations of men and women are vulnerable to greater hurdles in their access to prevention strategies and treatment intervention. Numerous studies have identified different patterns of smoking behavior and disproportionate consequences of smoking not only between genders but also within gender, for example that among some racial and ethnic subpopulations of women [7, 8].

We have used fundamental concepts and definitions from the general health-disparities literature to examine smoking behavior among subpopulations of women, with a focus on three factors:

1. race and/or ethnicity;

2. educational status; and

3. acculturation.

We suggest that research on smoking behavior among subpopulations of women is beginning to reveal not only different smoking behavior but also disparities across women in different subpopulations. We propose that application of the definitions and methodological approaches used in the general health-disparities literature to research on smoking behavior will assist in the development of intervention designed, targeted, and personalized for smoking cessation. Finally, we conclude that subpopulation-based understanding of gender differences and disparities in smoking is critical to improvement of research design, intervention objectives, and public health policy on smoking among women.

Defining health disparities

In 2000, the US Surgeon General’s office issued several landmark reports on tobacco use, detailing dramatic differences in tobacco use and attempts to quit by subgroups, and used the term “disparities” to refer to inequities in the availability of and access to smoking-cessation services [7, 8]. The term “disparities” was specifically used to refer to the higher levels of tobacco use and lower levels of access to necessary tobacco-cessation services among racial and ethnic minority groups compared with those available to the majority white population [7].

However, definitions of health-care disparities have not been consistent in the health services research literature. For example, both the Healthy People 2010 [9] and the AHRQ National Healthcare Disparities Reports [10] provide another definition of racial and ethnic disparities as “all differences among populations in measures of health and health care”. This broad definition does not take into account racial and/or ethnic group differences that many would consider appropriate in an equitable health care system, for example, different need for treatment (e.g., because of different health status) or treatment preferences. A third, more nuanced definition of disparities was coined by the Institute of Medicine (IOM). In its Unequal Treatment report [11] disparities are referred to as those “differences in health care services received by two groups that are not due to differences in the underlying health care needs or preferences of members of the groups”. According to the IOM, differences attributable to the need for or preferences for services should not be regarded as constituting a disparity, but differences attributable to socioeconomic status, gender, or other factors that are based on discriminatory practices should be regarded as disparities [12].

Recently, the IOM definition of disparities has been integrated into the substance abuse treatment literature [12] and, we argue, has relevance to the conduct of research and implementation of policy on smoking behavior. The IOM definition has particular relevance to understanding disparities related to smoking in subpopulations of women, because many factors affecting whether women receive effective cessation intervention depend upon unbiased health-care systems and the conduct of research designed and implemented to develop gender-specific intervention for smoking.

Applying the IOM definition of disparities to subpopulations of women who smoke

Implementation of the IOM definition of health care disparities requires use of analytical methods different from those used to compare means across groups (e.g. women vs. men, African–American women vs. white women). Specifically, the IOM definition requires analytical techniques that distinguish between differences due to a given set of characteristics (defined by clinical need and patient preferences) and differences due to all other factors. Analysis is required that adjusts for number of cigarettes smoked, mental health status, and treatment preferences, and which can be used to investigate how factors such as perceived gender discrimination, educational status, race and/or ethnicity, and acculturation contribute to disparities in utilization of smoking-cessation services. One specific method is to ensure independent variables are classified into two categories—those to be adjusted (need) and those included in the disparity calculation (e.g. educational status, race and/or ethnicity, and acculturation).

Below we utilize the IOM definition of disparities to summarize some of the emergent results from research on disparities in smoking behavior among subpopulations of women specific to educational status, race and/or ethnicity, and acculturation. The articles we highlight utilize analytical methods and study designs that enable conclusions to be drawn about the existence and extent of disparities on the basis of the IOM definition of disparity.

Disparities in smoking behavior and utilization of smoking-cessation treatments among subpopulations of women

Despite identification of factors associated with gender differences in smoking behavior, smoking research in the US has paid fragmented attention to subpopulations of women, focusing primarily on smoking in samples of white women seeking treatment. Consequently, our knowledge about disparities in smoking within subpopulations of women is limited. In this section, we specifically discuss disparities in access to and utilization of smoking-cessation treatment with particular focus on educational status, race and/or ethnicity, and acculturation. We conclude that, despite continuing progress in documenting the variability in smoking behavior and related consequences for subpopulations of women, much additional gender-specific smoking research that adheres to the IOM definition of disparities is still needed.

“First and worst”

Health disparities researchers use the term “first and worst” to refer to the earlier disease onset and greater severity of disease often manifest among racial and ethnic minorities [13]. The “first and worst” concept is one that, although unfortunate, aptly describes disparities in smoking among women and, in particular, among subpopulations of women. Specific to women in general, a recent review of studies documenting differences between smoking by women and men [14] found that women maintain their nicotine addiction with lower levels of nicotine intake than men (e.g. “first”) and are more vulnerable to the adverse health consequences of smoking, for example lung cancer (e.g. “worst”) [15]. The “first and worst” concept also describes smoking behavior among African–American women in that, compared with white women, African–American women are more likely to initiate smoking at an earlier age (e.g. “first”) [16, 17] and are more likely to be diagnosed with lung cancer when the cancer is at a more advanced stage [18], to have more aggressive forms of cancer that are resistant to treatment [19–21], and to have what are called “triple-negative tumors” (tumors that grow more quickly, and kill more frequently) (e.g. “worst”) [19–21], despite being more likely to be “light” smokers (adults smoking fewer than 10 cigarettes a day) than white Americans [22]. Mortality from lung cancer is also greater among African–American women aged 35–64 than among white women of similar age [23]. In short, although the prevalence of smoking among African–American women is lower than among white women, the different ages at initiation lead to disparities in health outcomes [24, 25].

The effect of educational status, race and/or ethnicity, and acculturation on smoking among women

Although educational status and other variables related to socioeconomic position account for many of the health disparities, race and/or ethnicity can be an added factor that is linked to poor health. In recent data from the National Survey on Drug Use and Health among adults aged 18 and older, 21 % of non-Hispanic African–American women and 16 % of Hispanic women reported smoking, with the highest prevalence among low income (32 %) and unemployed (41 %) women and women with less than a high school diploma (26 %) [26]. Next we elaborate on two important variables in health-disparities research—educational status and race and/or ethnicity—as separate factors affecting women’s smoking behavior.

Educational status

There is increasing evidence that education has a distinct effect on smoking behavior. Almost uniformly, findings indicate that women with little education are a particularly high-risk group. Education has affected not only the number of both young and old women who have never smoked but also the growing proportion of former smokers among highly educated women. In 2010, the prevalence of current smoking among female college graduates age 25–34 was almost 20 percentage points lower (9 % versus approximately 30 %) than for other education groups, and the prevalence of never smoking was comparable (79 % versus 58 %) [27]. The lower the level of education, the greater the risk of being a current smoker, smoking daily, smoking heavily, being nicotine-dependent, starting to smoke at an early age, having higher levels of circulating cotinine per cigarette smoked, and continuing to smoke in pregnancy [28]. This educational disadvantage also has a pervasive negative effect on the second generation; their offspring are more likely to smoke and to have behavior problems [29].

Race and/or ethnicity

Understanding differences and disparities in cigarette smoking requires heterogeneity in smoking patterns by gender and race and/or ethnicity to be well documented and understood, given the rapidly changing composition of the US population [30], and a growing body of research is documenting racial and/or ethnic disparities in cigarette smoking [31]. Prevalence and type of smoking among African–American women are different from those among white women. One example is the proportion of light smokers (adults smoking fewer than 15 cigarettes a day), which is higher among African–Americans (59.2 %) than among white Americans (29.1 %) [32] and higher among African–American women (63 %) than among African–American men (53 %) [33].

Specific to disparities in smoking cessation, racial and ethnic minority women smokers are less likely to receive advice to stop smoking, to use recommended treatments to aid cessation, or to be successful in achieving or maintaining abstinence than their white counterparts with the same frequency of smoking [34, 35]. An exception is the implementation of home smoking restrictions, i.e. the practice of voluntarily adopting rules to limit or ban cigarette smoking in the home. Home smoking restrictions were more likely to be adopted (after an initial motivational interview encouraging their use) by African–American female smokers than by male smokers or white female smokers [33]. Within gender and broad racial and ethnic categories, there are many other groups, for example Asian–American subgroups, with diverse health needs and different barriers to gaining access to care for whom we have little information about access to smoking-cessation treatment [36]. Misconceptions of racial and ethnic minority populations, for example Black, Hispanic and Asian populations, as monolithic groups lacking within-group diversity, function as barriers to attempts to direct smoking-cessation efforts and could be a factor contributing to inequalities in the availability, use, and quality of treatment services among female, racial and ethnic minority groups.

Acculturation: migration and smoking among subpopulations of women

A comprehensive examination of gender disparities in smoking in accordance with the IOM definition should consider patterns of migration and their effect on smoking initiation and cessation between women. From other research on health disparities, we know of the powerful effect of migration on health. Almost universally across health outcomes, all racial and ethnic groups have better outcomes than their counterparts born in the United States, irrespective of gender [37]. In general, the longer an immigrant remains in the United States, the worse his or her health becomes, such that declines in health outcomes are seen with increasing generational status.

How long a population or person has resided in the US, and the extent to which US cultural norms have been adopted by the person or population, have been shown to substantially affect smoking behavior. Specific to Asian–American female smokers, acculturation seems to increase the risk of cigarette smoking [38]. In a meta-analysis that examined the prevalence of smoking among Asian women and the effect of acculturation, most commonly measured as proficiency in English, the average effect size for women was 5.26 (2.75–10.05), suggesting that acculturated Asian women are five times more likely to smoke than Asian women who maintain traditional Asian values. Among adolescents, the average effect size was 1.92 (1.22–3.01), indicating that acculturated adolescents are almost two times more likely to smoke than traditional adolescents [39].

Specific to Hispanic subpopulations, surveys indicate that Mexican–Americans smoke less than many other Hispanic subgroups including Cubans and Puerto Ricans [40] and Mexican–Americans have exceptionally low cigarette consumption, with a large fraction of smokers self-identified as “intermittent” or “occasional” rather than “daily” smokers [41]. Recent results confirm that the Hispanic advantage is not consistent among all Hispanic subgroups of women. For example, US-born Hispanic women are more likely to smoke than white women, and foreign-born Hispanic women consume many fewer cigarettes daily [42]. Smoking-related mortality for US born, non-Mexican– American Hispanic women (24 %) is higher than for white women and white men [42] with a similar smoking habit. Overall, future research must include studies of subpopulations of racial and ethnic minority women with a focus on diverse measures of acculturation including, but not limited, to language proficiency.

Conclusion

Although the prevalence of cigarette smoking among women in the US has decreased over the last three to four decades, it has emerged that race and/or ethnicity, acculturation, and educational status all substantially affect the prevalence of smoking and other smoking behavior among women [1]. We provide evidence of different smoking behavior among subpopulations of women, of disparities in access to care, and of exposure to cultural factors that affect smoking. We have also summarized major findings among subpopulations of women in accordance with the IOM definition of disparities both from national surveys and from smaller, treatment-seeking and community samples. We invoke the IOM definition of disparities because we believe it correctly separates needs or preferences for health care from the lack of access or availability of appropriate health care, and calls attention to the need for statistical methods that compare means across groups while maintaining constant the variables that determine need for smoking-cessation treatment.

Although progress continues to be made in documenting variability in smoking behavior and related consequences for subpopulations of women, much additional research is still needed. For example, large national surveys provide limited data enabling examination of factors explaining disparities in smoking behavior much beyond social demographic variables. To conform with the IOM definition of disparities, research must maintain a systematic, strong, and growing focus on subpopulations of women smokers to enable further understanding of how education, discrimination, and immigration affect observed gender differences in the extent of smoking and other comorbid conditions. Furthermore, elucidating the extent to which observed gender differences in smoking may be because of methodological discrepancies across studies and/or environmental and psychosocial factors unique to women and specific to specific subpopulations of women has particular health relevance. For example, clarifying the methodological and contextual factors that affect smoking among subpopulations of women will facilitate future epidemiologic studies and enable the design of cessation intervention for, and policy changes directed at, specific groups of smokers—an objective conforming with the current movement toward personalized medicine.

Personalized medicine as applied to smoking-cessation intervention for women necessitates better understanding of underlying differences within and between groups of women to enable identification of characteristics of subpopulations that enable prediction of smoking cessation and help match smokers with a strategy that is more likely to help them quit, ultimately reducing disparities in smoking. To summarize, a more nuanced gender-specific framework is needed to examine how gender differences occur in subpopulations of women as potential disparities, and how their existence can affect the development of research and tobacco-control policies that are sensitive to the subpopulations of women most at risk.