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. Author manuscript; available in PMC: 2014 Aug 16.
Published in final edited form as: ACS Chem Biol. 2013 May 29;8(8):1730–1736. doi: 10.1021/cb4000986

Figure 4. Alverine and Benfluorex are HNF4α activators.

Figure 4

T6PNE cells were treated with 0.5µM or 1µM tamoxifen and either 20µM alverine, 20µM, 80µM benfluorex for 3 days and 5µM BI6015 for 2 days or vehicle (DMSO). mRNA levels were normalized to 18S rRNA. BI6015 repressed genes selected from previously published microarray from HNF4α antagonist (Gene Expression Omnibus database-GSE33432) compared to DMSO. Values represent the mean ± SEM, 0.5µM tamoxifen with DMSO vs alverine, benfluorex and 1.0µM tamoxifen with DMSO vs. BI6015, *p<0.05, n=3 biological replicates.