Skip to main content
. Author manuscript; available in PMC: 2014 Feb 12.
Published in final edited form as: European J Org Chem. 2012 Jul 4;2012(24):4541–4547. doi: 10.1002/ejoc.201200695

Table 2.

Single-step NCA radiofluorination of diaryliodonium salts bearing azidomethyl groups in DMF.

graphic file with name nihms-524500-t0006.jpg
Entry Substrate Conditions[a]
 RCY [%][b]
Temp
[°C]		 Time
[s]		 [18F]Click
synthon		 Ar18F
1 5 160 188 [18F]2a, 37 1.8
2 6 180 188 [18F]2b, 41 <0.7
3 7 180 188 [18F]2c, 39 0.9
4 8 160 188 [18F]2a, 14 0
5 11 200 94 [18F]2a, 45 2.2
6 12 200 94 [18F]2a, 40 2.4
7 13 200 188 [18F]2a, 38 1.7
8 14 180 157 [18F]2c, 35 0.8
[a]

Conditions giving optima l RCYs from ~ 8 runs under various conditions.

[b]

RCYs we re determined chromatographically and are corrected for radioactivity adsorption; adsorption was 19 ± 7% (mean ± SD, n = 8).