. Author manuscript; available in PMC: 2014 Feb 12.

Published in final edited form as: European J Org Chem. 2012 Jul 4;2012(24):4541–4547. doi: 10.1002/ejoc.201200695

Table 4.

Radiofluorination of diaryliodonium salts under ‘wet’ conditions.


Entry	substrate^[a]	conditions		RCY [%]^[b]

		Temp. [°C]	Time [S]	[¹⁸F]Fluoro- benzyl azide	[¹⁸F]4- Fluoro anisole
1	3	200	188	[¹⁸F]2a, 17	1
2	8	200	188	[¹⁸F]2c, 46	1
3^[c]	8	180	94	[¹⁸F]2c, 53	2

^[a]

5 mM in DMF.

^[b]

Optimal RCY from 6-8 different runs under different conditions, determined chromatographically with correction for radioactivity adsorption; adsorption in the microfluidic apparatus was 29 ± 2% (n = 3, mean ± SD).

^[c]

Reaction performed in MeCN.