Table 1.
Selected Studies Examining Intermediate- (2- to 10-Year) and Long-term (≥ 10 Years) Urinary Continence and Function Outcomes in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer
| Study | Length of Follow-up (y) | Study Design (Baseline?) | Number of Eligible RP Patients | Definition of Continence/Continence Scale | Results |
|---|---|---|---|---|---|
| Intermediate-term Studies (2–10 y) | |||||
| Parker WR et al68 | 5 | Prospective, longitudinal (baseline) | 382 | EPIC Incontinence Domain | EPIC scores plateau at 1 y and stable until 5 y |
| Miller DC et al38 | 6.2 (median) | Prospective, longitudinal cohort (no baseline) | 994 (665 RP) | EPIC Incontinence Domain | EPIC scores stable from 2.6–6.2 y median follow-up |
| Nandipati KC et al55 | 7.2 (mean) | Prospective, longitudinal (no baseline) | 152 | Continence: ≤ 1 pad per day | Incontinence rate increased from 2 y to mean 7.2 y follow-up (12.5–17.7%, P unknown) Nerve-sparing improved long-term continence rate |
| Long-term Studies (≥ 10 y) | |||||
| Prabhu V et al.74 (NYUPLOS) | 10 | Prospective, longitudinal (baseline) | 1788 | Continence: ≤ 1 pad per day UCLA-PCI-UFI | Incontinence increased from 2–10 y (4.5–8.9%; P = .024), UCLA-PCI-UFS decreased from 2–8 y (83.8–81.8; P = .007) and 8–10 y (81.8–79.6; P = .04) Both results more prominent in men ≥ 60 y |
| Resnick MJ et al.51 (PCOS) | 15 | Prospective, longitudinal (baseline recalled) | 1164 | Continence: no control or frequent urinary leakage UCLA-PCI-UFI | Incontinence increased from 2–5 to 15 y (9.6–13.4 to 18.3%; P unknown) “Slight decline” in mean UCLA-PCI-UFS from 5–15 y |
EPIC, Expanded Prostate cancer Index Composite; LUTS, lower urinary tract symptoms; NYUPLOS, New York University Prospective Longitudinal Outcomes Study; PCI, Prostate Cancer Index; RP, radical prostatectomy; PCOS, Prostate Cancer Outcomes Study; UCLA-PCI-UFI, UCLA-PCI-Urinary Function Index; UCLA-PCI-UFS, UCLA-PCI-Urinary Function Score.