Fig 7.

Stimulation of EPC chemotaxis by hypoxia-conditioned HUVEC media and blockade by anti-MIF and anti-CXCR4 antibodies. Hypoxia-conditioned HUVEC supernatants but not normoxia-conditioned control media promotes EPC chemotaxis and this effect is abolished by anti-MIF antibodies (A). (B) as in (A), but blockade by anti-CXCR4 antibodies. The hypoxia-conditioned HUVEC media were added to the lower chamber of a Transwell device. Bars represent mean values ± S.D. (n= 3). Asterisks, ***, indicates statistical significance with P < 0.005.