Table 2.
Mean systemic arterial blood pressure (MAP), heart rate (HR) and basal left ventricular echocardiographic parameters
|
Genotype |
Wt
|
Wt
|
Hif1a
+/-
|
Hif1a
+/-
|
|---|---|---|---|---|
| Parameter | Non-diabetic | Diabetic | Non-diabetic | Diabetic |
| Males (n) |
6 |
8 |
10 |
8 |
| MAP (mmHg) |
83.0 ± 2.1 |
87.5 ± 1.5 |
84.1 ± 1.4 |
88.2 ± 1.6 |
| HR (beats/min) |
496 ± 23 |
471 ± 13 |
449 ± 40 |
440 ± 36 |
| LVDD (mm) |
3.60 ± 0.09 |
3.59 ± 0.04 |
3.47 ± 0.10 |
3.65 ± 0.06 |
| LVDS (mm) |
2.22 ± 0.07 |
2.27 ± 0.05 |
2.16 ± 0.08 |
2.42 ± 0.07 |
| AWTD (mm) |
0.84 ± 0.02 |
0.76 ± 0.01 |
0.89 ± 0.02 |
0.74 ± 0.03†* |
| PWTD (mm) |
0.84 ± 0.03 |
0.76 ± 0.01 |
0.92 ± 0.04 |
0.69 ± 0.03†* |
| AWTS (mm) |
1.30 ± 0.03 |
1.20 ± 0.04 |
1.27 ± 0.03 |
1.10 ± 0.05†* |
| PWTS (mm) |
1.21 ± 0.03 |
1.09 ± 0.03 |
1.20 ± 0.04 |
1.00 ± 0.04†* |
| Females (n) |
7 |
12 |
10 |
8 |
| MAP (mmHg) |
84.6 ± 2.1 |
88.5 ± 2.2 |
84.8 ± 0.04 |
88.1 ± 1.3 |
| HR (beats/min) |
504 ± 7 |
478 ± 15 |
484 ± 16 |
449 ± 17 |
| LVDD (mm) |
3.52 ± 0.08 |
3.52 ± 0.06 |
3.45 ± 0.04 |
3.46 ± 0.04 |
| LVDS (mm) |
2.33 ± 0.07 |
2.37 ± 0.06 |
2.30 ± 0.05 |
2.43 ± 0.06 |
| AWTD (mm) |
0.75 ± 0.02 |
0.75 ± 0.01 |
0.72 ± 0.02 |
0.72 ± 0.02 |
| PWTD (mm) |
0.79 ± 0.02 |
0.74 ± 0.02 |
0.78 ± 0.03 |
0.74 ± 0.02 |
| AWTS (mm) |
1.12 ± 0.04 |
1.05 ± 0.02 |
1.06 ± 0.01 |
0.98 ± 0.02†* |
| PWTS (mm) | 1.10 ± 0.02 | 1.05 ± 0.02 | 1.09 ± 0.02 | 0.99 ± 0.02* |
Values are mean ± SEM. LVDD - diastolic cavity diameter, LVDS - systolic cavity diameter, AWTD - diastolic anterior wall thickness, PWTD - diastolic posterior wall thickness, AWTS - systolic anterior wall thickness, PWTS - systolic posterior wall thickness. Statistical significance was assessed by 2-way ANOVA with Tukey’s multiple-comparison test, *P < 0.05 vs. non-diabetic Wt, †P < 0.05 vs. non-diabetic Hif1a +/- .