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. 2013 Nov 18;592(Pt 2):313–324. doi: 10.1113/jphysiol.2013.261099

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©2013 The Authors. The Journal of Physiology © 2013 The Physiological Society

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Periodic insertion of new activator peaks along the growing Y-stalk A, each new activator peak emerges directly behind the leading activator peak. The sequence of emergence is marked 1, 2 and 3. Side branches then grow out of the activator peaks. B, in lung development, daughter branches bud off from the main stalk in the same sequence. Branches marked 1 and 2 formed in that order, and a new branch 3 is forming. The asterisk denotes the primary bud (Weaver et al. 1999, 2000). Note also that the branching is biased to one side. C, similar biased side branching is seen in a simulation of two closely spaced trunks. Parameters: , , , , , , , , , , , , , .

Inline graphic — Periodic insertion of new activator peaks along the growing Y-stalk A, each new activator peak emerges directly behind the leading activator peak. The sequence of emergence is marked 1, 2 and 3. Side branches then grow out of the activator peaks. B, in lung development, daughter branches bud off from the main stalk in the same sequence. Branches marked 1 and 2 formed in that order, and a new branch 3 is forming. The asterisk denotes the primary bud (Weaver et al. 1999, 2000). Note also that the branching is biased to one side. C, similar biased side branching is seen in a simulation of two closely spaced trunks. Parameters: , , , , , , , , , , , , , .