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. 2013 Nov 18;592(Pt 2):313–324. doi: 10.1113/jphysiol.2013.261099

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©2013 The Authors. The Journal of Physiology © 2013 The Physiological Society

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Domain branching: spatial intervals and orthogonal rotation of the branching plane A, decreases in the net production rate of substrate S (via the parameter c₀) decreased the spatial frequency, but only when c₀ decreased beyond a certain threshold. Values for c₀ were 0.02 (left), 0.015 (middle) and 0.008 (right). B, increasing the inhibition between activator peaks, by either up-regulating the secretion of inhibitor H by Y cells (ρ_H increased from 0.000025 to 0.0001) or down-regulating the secretion of activator A by Y cells (ρ_A decreased from 0.025 to 0.0008), enlarges the spatial intervals between activator peaks. Ca, in 3D simulation, the Y-stalk developed its first generation of side branches in the horizontal plane. Cb, at a later stage, a secondary row of branches emerged perpendicularly to the previous horizontal plane. (Parameters:, , , , , , , , , , , , , .)

Inline graphic — Domain branching: spatial intervals and orthogonal rotation of the branching plane A, decreases in the net production rate of substrate S (via the parameter c₀) decreased the spatial frequency, but only when c₀ decreased beyond a certain threshold. Values for c₀ were 0.02 (left), 0.015 (middle) and 0.008 (right). B, increasing the inhibition between activator peaks, by either up-regulating the secretion of inhibitor H by Y cells (ρ_H increased from 0.000025 to 0.0001) or down-regulating the secretion of activator A by Y cells (ρ_A decreased from 0.025 to 0.0008), enlarges the spatial intervals between activator peaks. Ca, in 3D simulation, the Y-stalk developed its first generation of side branches in the horizontal plane. Cb, at a later stage, a secondary row of branches emerged perpendicularly to the previous horizontal plane. (Parameters:, , , , , , , , , , , , , .)