Table 1.
Estimated vascular parameters from DCE-MRI data (means ± SD)
| Model parameter (unit)* | Control (n = 9) | Col15a1−/− (n = 10) | Col18a1−/− (n = 10) |
|---|---|---|---|
| Permeability (× 10−6 cm s−1) | 8.8 ± 2.3 | 16.0 ± 3.2† | 13.4 ± 3.0† |
| Blood flow (ml (100 g)−1 min−1) | 17.7 ± 6.6 | 15.5 ± 3.4 | 24.5 ± 8.2 |
| Blood volume (ml (100 g)−1) | 2.7 ± 0.7 | 2.8 ± 0.6 | 2.8 ± 0.6 |
| Transit time (s) | 10.5 ± 4.8 | 11.2 ± 2.6 | 7.3 ± 1.9 |
| Extraction fraction | 0.53 ± 0.05 | 0.65 ± 0.02† | 0.59 ± 0.07 |
| Blood flow × extraction (ml (100 g)−1 min−1) | 9.2 ± 3 | 9.9 ± 1.9 | 14.1 ± 4.0† |
| PS product (ml (100g)−1 min−1) | 9.7 ± 3.1 | 11.6 ± 2.5 | 15.4 ± 4.4† |
| PS/blood flow (min−1) | 0.55 ± 0.03 | 0.71 ± 0.03† | 0.65 ± 0.03† |
| Ktrans | 6.8 ± 2.3 | 7.1 ± 1.33 | 10.2 ± 2.9† |
| Extracellular volume (ml (100 g)−1) | 25.7 ± 7.4 | 18.3 ± 3.4† | 25.2 ± 4.9 |
| kep | 0.37 ± 0.07 | 0.55 ± 0.06† | 0.56 ± 0.13† |
*
Permeability values in first row were estimated with the step–slope model, whereas the other vascular parameters were estimated using the single channel blind deconvolution and the adiabatic approximation tissue homogeneity model.
†
P < 0.05 compared to control.