Table 2.
Effect of Rabbit Hemorrhagic Disease virus (RHDV) infection on mRNA levels of genes related to autophagy
| Control | 12 h | 18 h | 24 h | 30 h | 36 h | |
|---|---|---|---|---|---|---|
| Beclin-1 |
100 ± 11 |
118 ± 8 |
203 ± 16* |
253 ± 36* |
105 ± 6 |
87 ± 7 |
| UVRAG |
100 ± 6 |
104 ± 8 |
227 ± 19* |
131 ± 15 |
81 ± 9* |
99 ± 5 |
| Atg5 |
100 ± 5 |
125 ± 11* |
163 ± 19* |
139 ± 7* |
87 ± 7 |
63 ± 5 |
| Atg12 |
100 ± 9 |
173 ± 12* |
296 ± 41* |
177 ± 9* |
104 ± 8 |
82 ± 7 |
| Atg16L1 |
100 ± 10 |
106 ± 9 |
223 ± 6* |
140 ± 12* |
130 ± 7* |
106 ± 10 |
| p62/SQSTM1 |
100 ± 4 |
145 ± 6* |
192 ± 8* |
202 ± 8* |
86 ± 6 |
69 ± 4* |
| BiP |
100 ± 7 |
118 ± 17 |
177 ± 41* |
304 ± 29* |
241 ± 39* |
184 ± 18* |
| CHOP |
100 ± 8 |
169 ± 10* |
211 ± 19* |
540 ± 79* |
158 ± 9* |
161 ± 13* |
| GRP94 | 100 ± 4 | 80 ± 4* | 163 ± 5* | 412 ± 54* | 314 ± 13* | 226 ± 21* |
Levels of mRNA were analyzed by real-time PCR assays. Data, normalized against β-Actin, are presented as percentage change from the control group. Values are expressed as means±S.E.M (n = 6). *P<0.05, compared with Control.