Table 3.

Test diagnostics of sample definitions of pathologic significance

	Pathologic Findings (≥pT3 or Gleason >6 of Any Size)
Epstein’s Clinical Criteria Alone	Significant Disease	Insignificant Disease

Significant Disease	46	21	PPV = 69%

Insignificant Disease	12	25	NPV = 68%

	Sensitivity = 79%	Specificity = 54%

	Pathologic Findings (≥pT3 or Gleason >6 of Any Size)
Epstein’s Clinical Criteria or ADC<850 µm²/sec	Significant Disease	Insignificant Disease

Significant Disease	54	25	PPV = 68%

Insignificant Disease	4	21	NPV = 84%

	Sensitivity = 93%	Specificity = 46%

	Pathologic Findings (≥pT3, or Gleason ≥4+3, or Gleason 3+4 and ≥1.3 mL)
Epstein’s Clinical Criteria Alone	Significant Disease	Insignificant Disease

Significant Disease	44	23	PPV = 66%

Insignificant Disease	10	27	NPV = 73%

	Sensitivity = 82%	Specificity = 54%

	Pathologic Findings (≥pT3, or Gleason ≥4+3, or Gleason 3+4 and ≥1.3 mL)
Epstein’s Clinical Criteria or ADC<850 µm²/sec	Significant Disease	Insignificant Disease

Significant Disease	52	27	PPV = 66%

Insignificant Disease	2	23	NPV = 92%

	Sensitivity = 96%	Specificity = 46%

Abbreviations as in Table 1.