Table 11.

CLINICAL PATTERNS OF NEUROPATHIC DISORDERS

	Weakness
	Prox	Dis	Asymm	Symm	Sensory Symptoms	Severe Proprioceptive Loss	UMN Signs	Autonomic Symps/Signs	Diagnosis
Pattern 1 - Symmetric prox & Distal weakness w/sensory loss	+	+		+	+				GBS/CIDP
Pattern 2 - Distal sensory loss with/without weakness		+		+	+				CSPN, metabolic, drugs, hereditary
Pattern 3 - Distal weakness with sensory loss		+	+		+				Multiple – Vasculitis, HNPP, MADSAM, infection Single – Mononeuropathy, radiculopathy
Pattern 4 - Asymmetric prox & distal weakness w/sensory loss	+	+	+		+				Polyradiculopathy, plexopathy
Pattern 5 - Asymmetric distal weakness w/out sensory loss		+	+				+/−		+ UMN – ALS Pure UMN - PLS - UMN – MMN, PMA, MAMA, BAD, LAD
Pattern 6 - Symmetric sensory loss & upper motor neuron signs		+		+	+	+	+		B12 defic; Copper deficiency, Friedreich’s, adrenomyeloneuropathy
Pattern 7* Symmetric weakness without sensory loss	+/−	+		+					Prox & Distal SMA Distal Hereditary motor neuropathy
Pattern 8* Focal midline proximal symmetric weakness	+ Neck/extensor + Bulbar			+ +			+ +		ALS
Pattern 9 - Asymmetric proprioceptive loss w/out weakness			+		+	+			Sensory neuronopathy (ganglionopathy)
Pattern 10 - Autonomic dysfunction								+	HSAN, diabetes, GBS, amyloid, porphyria, Fabry’s

^*Overlap patterns with myopathy/NMJ disorders

Legend:

ALS amyotrophic lateral sclerosis

BAD brachial amyotrophic diplegia

CIDP chronic inflammatory demyelinating polyneuropathy

CSPN cryptogenic sensory polyneuropathy

GBS Guillain-Barré syndrome

HNPP hereditary neuropathy with liability to pressure palsy

HSAN hereditary sensory and autonomic neuropathy

LAD leg amyotrophic diplegia

LMN lower motor neuron

MADSAM multifocal acquired demyelinating sensory and motor

MAMA multifocal acquired motor axonopathy

MMN multifocal motor neuropathy

PMA progressive muscular atrophy

SMA spinal muscular atrophy

UMN upper motor neuron