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Effect of ERK1/2 inhibitor PD-98059 on Elk-1 activity. ERK1/2 inhibitor PD-98059 (100 μM) prevented the IL-1β-induced activation of Elk-1 as assessed by ELISA-binding assay (means ± S.E., n= 5). *P < 0.0001 versus control; **P < 0.001 versus IL-1β treatment.
