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. 2010 Apr 7;15(4):970–982. doi: 10.1111/j.1582-4934.2010.01065.x

Fig 12.

Fig 12

Proposed scheme of the IL-1β-induced increase in intestinal epithelial TJ permeability. IL-1β treatment resulted in activation of ERK1/2 signalling cascade, which then caused an activation of Elk-1- and Elk-1-induced activation of MLCK gene and increase in MLCK protein expression (* indicated activation of ERK1/2 and Elk-1 upon phosphorylation).