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. 2014 Jan 28;15:76. doi: 10.1186/1471-2164-15-76

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Copyright © 2014 Cieślik and Bekiranov; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Epigenetic reprogramming of the pluripotency network. Association of histone modification changes and NMF codes with genes involved in pluripotency. Myc/Max, Nanog, Oct4, Sox2 are shorthand for experimental targets of these TFs in human embryonic stem cells. PluriNet are genes involved in the protein-protein interactions networks discovered in pluripotent cells. Stem are genes up-regulated in embryonic stem cells shared between mouse and human. The five marks or codes most significantly (p-value) associated with each group of genes are shown.