Table 4.
The frequency of major drug resistance mutations and resistance complexes associated with PIs, NRTIs and NNRTIs of the 89 genotyped patients
| NNRTI-based regimen (n = 73) | PI-based regimen (n = 16) | |||
|---|---|---|---|---|
|
NNRTI mutations |
Number |
Percentage |
Number |
Percentage |
| Any NNRTI DRM |
60 |
82.2 |
4 |
25.0 |
| L100I |
5 |
6.9 |
0 |
0 |
| K101EP |
6 |
8.2 |
0 |
0 |
| K103NRS |
46 |
63.0 |
2 |
12.5 |
| V106M |
23 |
31.5 |
2 |
12.5 |
| V108I |
7 |
9.6 |
1 |
6.3 |
| Y181C |
2 |
2.7 |
0 |
0 |
| Y188HCL |
7 |
9.6 |
1 |
6.3 |
| G190AS |
9 |
12.3 |
1 |
6.3 |
| P225H |
14 |
19.2 |
0 |
0 |
| M230L |
3 |
4.1 |
0 |
0 |
|
NRTI mutations |
|
|
|
|
| Any mutation |
63 |
86.3 |
10 |
62.5 |
| M41L |
7 |
9.6 |
0 |
0 |
| K65NR |
4 |
5.5 |
1 |
6.3 |
| D67NG |
8 |
11.0 |
0 |
0 |
| K70ER |
7 |
9.6 |
0 |
0 |
| L74VI |
4 |
5.5 |
1 |
6.3 |
| Y115F |
3 |
4.1 |
2 |
12.5 |
| M184VI |
60 |
82.2 |
10 |
62.5 |
| L210W |
1 |
1.4 |
0 |
0 |
| T215FYI |
9 |
12.3 |
0 |
0 |
| K219QREN |
5 |
6.9 |
0 |
0 |
| Any TAMS |
22 |
30.1 |
0 |
0 |
| 1 TAM |
11 |
15.1 |
0 |
0 |
| 2 TAMs |
7 |
9.6 |
0 |
0 |
| ≥3 TAMs |
4 |
5.5 |
0 |
0 |
| Q151M complex |
1 |
1.4 |
1 |
6.3 |
|
PI mutations |
|
|
|
|
| Any PI mutation |
0 |
0 |
1 |
6.3 |
| V82A | 0 | 0 | 1 | 6.3 |