Figure 1. Model for GDISR. Infection of the intestine leads to induction of the p38 MAPK PMK-1, while DNA damage in germ cells activates the ERK1/2 MAPK MPK-1. MAPK signaling triggers transcriptional induction of innate immune genes that comprise putative secreted peptides. The innate immune response mediates pathogen resistance and, through activating the UPS, confers systemic stress resistance.