Table 2.

Pharmacokinetic variables of SIL after oral administration at the dose of 2.5 mg/kg to control rats and diabetic rat

Sr. no.	Group	AUCo-t (ug.h/ml)	AUC 0-∞ (ug.h/ml)	C max (ug)	Tmax (hr)	Kel	T 1/2
1	Control + SIL (2.5 mg/kg)	2.19 ± 0.052	0.5 ± 0.02	0.8 ± 0.05	1 hr	0.10 ± 0.01	6.93
2	STZ + SIL (2.5 mg/kg)	3.72 ± 0.098*	1.12 ± 0.09*	1.1 ± 0.1*	1 hrns	0.089 ± 0.002*	8.6*

Data are the mean ± SEM for 6 rats,

^*p < 0.01 compare to normal Control.