Table 1. Characteristics of studies investigating the association of P2RX7 gene rs2230912 polymorphism with mood disorders.* .
| ID | Study (first author, year, reference) | Ethnicity | Types of mood disorders | Types of case | Sample size | Frequencies of genotypes | HWE (P-value) | Results | |
| Case | Control | ||||||||
| 1 | Soronen 2011 [16] | Caucasian | UD/BD | Family cohorts | 450 | 1322 | NA | NA | S |
| 2 | Viikki 2011 [17] | Caucasian | UD | Clinical cohorts | 218 | 391 | available | >0.05 | NS |
| 3 | Lavebratt 2010 [18] | Caucasian | UD/dysthymia/mixed anxiety depression | Population cohorts | 435 | 2215 | available | >0.05 | NS |
| 4 | Grigoroiu-Serbanescu 2009 [19] | Caucasian(German/Romanian/Polish/Russian) | UD/BD | Clinical cohorts | 2085 | 2006 | available | >0.05 | NS |
| 5 | Green 2009 [20] | Caucasian | UD/BD | Population cohorts | 1710 | 1179 | NA | >0.05 | NS |
| 6 | Hejjas 2009 [21] | Caucasian | UD/BD | Clinical cohorts | 171 | 178 | available | >0.05 | NS |
| 7 | McQuillin 2009 [22] | Caucasian | BD | Population cohorts | 587 | 546 | available | >0.05 | S |
| 8 | Yosifova 2009 [23] | Caucasian | BD | Clinical cohorts | 94 | 184 | NA | >0.05 | NS |
| 9 | Lucae 2006 [24] | Caucasian | UD | Clinical cohorts | 999 | 1029 | available | <0.05 | S |
| 10 | Barden 2006 [25] | Caucasian | BD | Family cohorts | 213 | 212 | available | >0.05 | S |
*HWE: Hardy–Weinberg equilibrium; UD: unipolar depression; BD: bipolar disorder; NA: not available; S: significant; NS: not significant.