Table 2. Meta-analysis of P2RX7 gene rs2230912 polymorphism and mood diorders association.^* .

Comparsions		Sample size		No. of Studies	Test of association				Test of heterogeneity
		Case	Control		OR (95%CI)	Z	P-value	Model	χ2		P-value	I2(%)
Overall	G vs A	13924	18524	13	1.05(0.96–1.15)	1.04	0.30	R	22.49		0.03	46.6
	AG+GG vs AA	4708	6577	10	1.08(0.94–1.24)	1.09	0.28	R	19.69		0.02	54.3
	GG vs AA+AG	4708	6577	10	0.87(0.68–1.11)	1.12	0.26	F	7.32		0.60	0.0
	GG vs AA	3367	4858	10	0.90(0.70–1.15)	0.85	0.39	F	7.52		0.58	0.0
	AG vs AA	4589	6397	10	1.10(0.95–1.27)	1.27	0.20	R	20.55		0.01	56.2
UD	G vs A	6540	10388	6	1.01(0.87–1.18)	0.17	0.86	R	13.21		0.02	62.2
	AG+GG vs AA	1964	2693	4	0.98(0.76–1.27)	0.14	0.89	R	9.42		0.02	68.1
	GG vs AA+AG	1964	2693	4	0.71(0.49–1.04)	1.77	0.08	F	0.26		0.97	0.0
	GG vs AA	1431	2023	4	0.73(0.50–1.07)	1.62	0.11	F	0.17		0.98	0.0
	AG vs AA	1921	2540	4	0.92(0.63–1.33)	0.44	0.66	R	17.97		0.0004	83.3
BD	G vs A	6514	11254	10	1.08(0.99–1.17)	1.74	0.08	F	13.20		0.15	31.8
	AG+GG vs AA	2309	2942	7	1.09(0.91–1.30)	0.92	0.36	R	11.48		0.07	47.7
	GG vs AA+AG	2309	2942	7	0.99(0.71–1.38)	0.05	0.96	F	5.47		0.48	0.0
	GG vs AA	1629	2149	7	1.02(0.73–1.42)	0.12	0.90	F	5.38		0.44	0.0
	AG vs AA	2242	2857	7	1.10(0.92–1.32)	1.02	0.31	R	11.27		0.08	46.8
Clinical cohorts	G vs A	7134	7576	8	0.96(0.84–1.11)	0.51	0.61	R	14.53		0.04	51.8
	AG+GG vs AA	3473	3604	7	1.00(0.83–1.20)	0.03	0.97	R	16.65		0.01	64.0
	GG vs AA+AG	3473	3604	7	0.78(0.58–1.04)	1.72	0.08	F	2.72		0.84	0.0
	GG vs AA	2510	2674	7	0.79(0.59–1.06)	1.57	0.12	F	2.71		0.84	0.0
	AG vs AA	3389	3492	7	1.02(0.83–1.25)	0.17	0.86	R	18.16		0.006	67.0
Population cohorts	G vs A	5464	7880	3	1.07(0.97–1.18)	1.31	0.19	F	3.24		0.20	38.2
Family cohorts	G vs A	1326	3068	2	1.26(1.05–1.50)	2.55	0.01	F	0.01		0.99	0.0

*UD: unipolar depression; BD: bipolar disorder; vs: versus; R: random effect model; F: fixed effect model.