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. 2014 Feb 12;9(2):e88571. doi: 10.1371/journal.pone.0088571

Figure 3. Colocalization of DLL1mEGF7 and DLL1mEGF3/4/7/8 protein with intracellular compartment markers.

Figure 3

Confocal images of cells stably expressing DLL1mEGF7 or DLL1mEGF3/4/7/8 co-stained with antibodies against DLL1 and the ER markers KDEL (a-f′) and Rab6A (g-l′), the trans-Golgi markers GM130 (m-r′) and Rab11 (s-x′), the endocytotic vesicle marker Caveolin (y-Ad′), and the early endosome markers EEA1 (Ae-Aj′) and Rab5 (Ak-As′). DLL1mEGF7 is present on the cell surface and intracellulary partially overlaping with KDEL, Rab6A and GM130, and to a lesser extent with Rab11, Caveolin, EEA1 and Rab5. The DLL1mEGF3/4/7/8 variant shows a similar distribution.