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. 2014 Jan 6;13:5. doi: 10.1186/1475-2840-13-5

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Copyright © 2014 Corella et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Longitudinal effect of the FAIM2-rs7138803 polymorphism on heart rate in type 2 diabetic subjects. Adjusted means of heart rate in beats per minute (bpm) depending on the polymorphism (GG + GA versus AA) at baseline, 1, 3 and 5-years of follow-up in all type 2 diabetic subjects at baseline having data for all four measurements (n = 1,076). Adjusted means were estimated from a repeated-measures ANOVA model with interaction terms adjusted for dietary intervention (MedDiet versus control), sex, age, BMI, medications, smoking, and physical activity. Adjusted P values for the interaction term among the polymorphism, time, and dietary intervention as well for the overall effect of the polymorphism are shown. *Adjusted P values for the polymorphism at every specific time point. Further adjustment of the model for hypertension at baseline did not change the statistical significance of the results.