Table 2.
Association between the FAIM2-rs7138803 and anthropometrical measures, blood pressure and heart rate
| |
FAIM2
(G > A) genotypes |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
GG (n = 3,019) |
GA (n = 3,235) |
AA (n = 907) |
Additive model |
|
|
Recessive model |
|||||||
| Mean | SD | Mean | SD | Mean | SD | P 1 | B 1 (95% CI) | P 2 | P 3 | B 1 (95% CI) | P 1 | P 2 | P 3 | |
| Weight (kg) |
76.4 |
± 11.9 |
76.9 |
± 11.9 |
77.3 |
± 12.1 |
0.026 |
0.46 (0.06-0.87) |
0.059 |
|
0.59 (-0.24-1.42) |
0.164 |
0.191 |
|
| BMI (kg/m2) |
29.9 |
± 3.8 |
30.0 |
± 3.9 |
30.1 |
± 3.9 |
0.055 |
0.13 (-0.01-0.26) |
0.023 |
|
0.20 (-0.07-0.47) |
0.147 |
0.066 |
|
| Waist circumference (cm) |
100.3 |
± 10.5 |
100.3 |
± 10.6 |
101.0 |
± 10.9 |
0.167 |
0.26 (-0.11-0.62) |
0.141 |
|
0.68 (-0.07-1.42) |
0.075 |
0.085 |
|
| SBP (mmHg) |
149.2 |
± 20.8 |
149.4 |
± 20.9 |
149.9 |
± 20.1 |
0.414 |
0.30 (-0.42-1.01) |
0.783 |
0.889 |
0.57 (-0.89-2.03) |
0.443 |
0.761 |
0.896 |
| DBP (mmHg) |
82.9 |
± 10.9 |
83.4 |
± 10.9 |
84.3 |
± 11.2 |
0.001 |
0.61 (0.24-1.00) |
0.006 |
0.015 |
1.12 (0.36-1.89) |
0.004 |
0.009 |
0.017 |
| Heart rate (bpm) |
71.1 |
± 11.2 |
71.2 |
± 10.9 |
72.3 |
± 11.4 |
0.029 |
0.43 (0.04-0.81) |
0.039 |
0.048 |
1.07 (0.29-1.86) |
0.007 |
0.010 |
0.012 |
| Prevalence of obesity (%) |
45.2 |
47.5 |
49.1 |
0.021 |
|
|
|
|
0.136 |
|
|
|||
| Obesity risk, OR (95% CI) | 1 (ref.) | 1.10 (0.99-1.21) | 1.17 (1.01-1.35) | 0.021 | 1.08 (1.01-1.16) | 0.011 | 1.11 (0.97-1.28) | 0.136 | 0.070 | |||||
Means, prevalence, odds ratios (OR), and regression coefficients (B).
Values are means and standard deviations (SD), odds ratio (OR) and 95% confidence intervals (CI) or regression coefficients (B) and 95% CI.
B: Regression coefficient per-variant allele effects in the additive model (genotypes coded as 0, 1 and 2 according to the number of minor alleles for additive effects) and regression coefficients for homozygotes for the variant allele versus the other genotypes in the recessive model (genotypes coded as 0 for GG and GA and 1 for AA).
SBP: Systolic blood pressure. DBP: Diastolic blood pressure.
1: Unadjusted P values for the polymorphism for the comparison of means or OR (in an additive or recessive models as indicated).
2: Models adjusted for sex, age, center, type 2 diabetes, medications (antihypertensive drugs, lipid-lowering drugs and antidiabetic drugs) and diagnosed hypertension.
3: Model 2 additionally adjusted for BMI. Further adjustment for total energy intake, adherence to Mediterranean diet and physical activity did not change the statistical significance of these associations.