Table 3.
Association between the FAIM2-rs7138803 polymorphism and categories of heart rate
| |
FAIM2
(G > A) genotypes |
Unadjusted
1
|
|
Adjusted
2
|
|
Adjusted
3
|
|
||
|---|---|---|---|---|---|---|---|---|---|
| Heart rate | GG + GA (n = 6,049) | AA (n = 888) | OR* (95% CI) | P 1 | OR* (95% CI) | P 2 | OR* (95% CI) | P 3 | |
| <60 bpm (%) |
90.1 |
|
9.9 |
1 (ref) |
|
1 (ref) |
|
1 (ref) |
|
| 60-70 bmp (%) |
87.3 |
|
12.7 |
1.32 (1.05-1.67) |
0.019 |
1.27 (1.00-1.60) |
0.051 |
1.26 (1.00-1.60) |
0.052 |
| 70-80 bmp (%) |
86.4 |
|
13.6 |
1.43 (1.13-1.82) |
0.003 |
1.46 (1.14-1.87) |
0.003 |
1.45 (1.13-1.86) |
0.003 |
| 80-90 bmp (%) |
86.1 |
|
13.9 |
1.46 (1.12-1.92) |
0.006 |
1.47 (1.10-1.97) |
0.009 |
1.46 (1.10-1.96) |
0.011 |
| > = 90 bmp (%) |
85.0 |
|
15.0 |
1.60 (1.13-2.27) |
0.008 |
1.65 (1.13-2.42) |
0.010 |
1.66 (1.13-2.43) |
0.009 |
| P for trend* | 0.002 | ||||||||
Prevalence and odds ratios (OR). Unadjusted and adjusted models.
Values are prevalences in%, odds ratio (OR) and 95% confidence intervals (CI).
OR: Odds ratio for the corresponding category of heart rate in comparison with the reference category (<60 bpm) for homozygous subjects for the variant allele (recessive model) in comparison with carriers of the major allele.
*: P-value of the Chi2 test for linear trend.
1: Unadjusted P values for the polymorphism (recessive model).
2: Models adjusted for sex, age, center, type 2 diabetes, hypertension, physical activity, medications, smoking, drinking, adherence to Mediterranean diet and total energy intake.
3: Model 2 additionally adjusted for BMI.