Table 1. Effect of C282Y-HFE on the expression of genes involved in lipoprotein signaling and cholesterol metabolism in human neuroblastoma SH-SY5Y cell lines.
| Gene (Gene Symbol) | Description | Fold changes (C282Y/WT) |
| APOA2 (APOA2) | Apolipoprotein A-II | 21.4 |
| APOD (APOD) | Apolipoprotein D | 161.0 |
| AD2/LPG (APOE) | Apolipoprotein E | 70.6 |
| Apo-F/DKFZp781G18150 (APOF) | Apolipoprotein F | 7.1 |
| APOL-II (APOL2) | Apolipoprotein L, 2 | 6.3 |
| BAL/BSDL (CEL) | Carboxyl ester lipase (bile salt-stimulated lipase) | 5.0 |
| HDLCQ10 (CETP) | Cholesteryl ester transfer protein, plasma | 8.5 |
| CLP1/NSR2 (COLEC12) | Collectin sub-family member 12 | 177.0 |
| CXCLG16/SR-PSOX (CXCL16) | Chemokine (C-X-C motif) ligand 16 | 305.7 |
| CYP39A1 (CYP39A1) | Cytochrome P450, family 39, subfamily A, polypeptide 1 | 28.8 |
| ELA3 (ELA3) | Elastase 3A, pancreatic | 38.5 |
| HMGCS2 (HMGCS2) | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 4.0 |
| BSF1/IL-4 (IL4) | Interleukin 4 | 7.8 |
| CL-6 (INSIG1) | Insulin induced gene 1 | 5.9 |
| ARH/ARH1 (LDLRAP1) | Low density lipoprotein receptor adaptor protein 1 | 25.4 |
| LRP-DIT/LRPDIT (LRP1B) | Low density lipoprotein-related protein 1B (deleted in tumors) | 198.2 |
| A2MRAP/A2RAP (LRPAP1) | Low density lipoprotein receptor-related protein associated protein 1 | 5.2 |
| NPC1L1 (NPC1L1) | NPC1 (Niemann-Pick disease, type C1, gene)-like 1 | 332.6 |
| SHP/SHP1 (NR0B2) | Nuclear receptor subfamily 0, group B, member 2 | 30.3 |
| FH/HCHOLA3 (PCSK9) | Proprotein convertase subtilisin/kexin type 9 | 66.5 |
| ACACT/ACAT (SOAT1) | Sterol O-acyltransferase 1 | 4.1 |
| CLEVER-1/FEEL-1 (STAB1) | Stabilin 1 | 8.0 |
| DKFZp434N127 (ZMYND15) | Zinc finger, MYND-type containing 15 | 19.9 |
| CP7B (CYP7B1) | Cytochrome P450, family 7, subfamily B, polypeptide 1 | -98.1 |
Pools of total RNA from WT- or C282Y-HFE stably transfected cells were analyzed using the GEArray human target specific gene array (Lipoprotein Signaling & Cholesterol Metabolism). Relative changes in mRNA levels between C282Y cells and WT cells are expressed as fold increase (positive number) or fold decrease (negative number). The average changes in expression (> 4 fold) are shown.