Table 3. Demographic and clinical variables of patients with newly acquired ICU needs after completion of tPA infusion.
| Characteristics | All patients (n = 119) | New ICU intervention by 24 hours (n = 8) | No ICU intervention (n = 111) | p-value |
| Age – years: mean (SD) | 64.7 (16.9) | 68.8 (18.9) | 64.4 (16.8) | 0.487 |
| range | 28–94 | 38–94 | 28–93 | |
| Race – n (%) | 0.348 | |||
| African American | 71 (59.7) | 3 (37.5) | 68 (61.3) | |
| Caucasian | 46 (38.7) | 5 (62.5) | 41 (36.9) | |
| Other | 2 (1.6) | 0 | 2 (1.8) | |
| Gender – female n (%) | 59 (49.6) | 3 (37.5) | 56 (50.5) | 0.479 |
| NIHSS – mean (SD) | 9.2 (5.67) | 17.3 (6.81) | 8.6 (5.14) | <0.001 |
| BP – mm Hg: mean (SD) | ||||
| SBP | 159 (28.5) | 159 (30.2) | 159 (28.5) | 0.995 |
| DBP | 90 (16.2) | 98 (15.5) | 89 (16.1) | 0.122 |
| tPA time window – n (%) | ||||
| 0–3 hour | 95 (79.9) | 7 (87.5) | 88 (79.3) | |
| 3–4.5 hours | 24 (20.1) | 1 (12.5) | 23 (20.7) | 0.576 |
| Glucose – mg/dl: mean (SD) | 138 (59.6) | 172 (63.7) | 136 (58.8) | 0.093 |
| eGFR <60 ml/min – n (%) | 41 (34.5) | 2 (25.0) | 39 (35.1) | 0.560 |
| INR – mean (SD) | 1.06 (0.14) | 1.06 (0.05) | 1.05 (0.14) | 0.745 |
| Distribution – n (%) | 0.950 | |||
| Anterior circulation | 101 (84.9) | 7 (87.5) | 94 (84.7) | |
| Posterior circulation | 17 (14.3) | 1 (12.5) | 16 (14.4) | |
| Both circulations | 1 (0.8) | 0 | 1 (0.9) | |
| Risk factors for stroke – n (%) | ||||
| Hypertension | 94 (79.0) | 8 (100) | 86 (77.5) | 0.131 |
| Hyperlipidemia | 66 (55.5) | 6 (75.0) | 60 (54.1) | 0.250 |
| Diabetes mellitus | 29 (24.4) | 5 (62.5) | 24 (21.6) | 0.009 |
| Atrial fibrillation | 25 (21.0) | 2 (25.0) | 23 (20.7) | 0.774 |
| Prior ischemic stroke | 30 (25.2) | 4 (50.0) | 26 (23.4) | 0.095 |
| Current smoking | 39 (32.8) | 1 (12.5) | 38 (34.2) | 0.206 |
| Medications – n (%) | ||||
| Antiplatelet agent | 58 (48.7) | 6 (75.0) | 52 (46.9) | 0.124 |
| Anticoagulation | 10 (8.4) | 0 | 10 (9.0) | 0.375 |
| Statin | 54 (45.4) | 4 (50) | 50 (45.1) | 0.786 |