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. 2014 Feb 12;9(2):e88642. doi: 10.1371/journal.pone.0088642

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© 2014 Wang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Meth markedly increased IL-6 mRNA expression, while MgTx obviously inhibited IL-6 enhancement mediated by Meth. (B, C) Meth triggered a slight but not statistically significant increasing in TNF-α and iNOS mRNA level, and MgTx showed no obvious effects on TNF-α and iNOs mRNA when co-treated with Meth. Each data point represents mean±SD of mRNA levels from at least three separate experiments in which treatments were performed in triplicates.* and ^# indicate significant differences compared with the control and condition stimulated by Meth respectively (p<0.05 by ANOVA).