Figure 7. XMetS improves glucose metabolism in multi-low dose, streptozotocin/high-fat diet mice.

A–C. ICR multi-low dose, streptozotocin/high-fat diet mice were treated twice weekly with either control antibody (10 mg/kg) or XMetS (10 mg/kg). Age-matched non-diabetic ICR mice were treated twice weekly with control antibody (10 mg/kg). A. Blood glucose levels were obtained weekly for six weeks following a 14-hour fast. B. After five weeks of treatment and following a 4-hour fast, insulin was administered intraperitoneally (0.75 U/kg) and blood glucose levels were obtained for an additional 120 minutes. C. After three weeks of treatment and following a 14-hour fast, a glucose bolus was administered intraperitoneally (1 g/kg) and blood glucose levels were measured for 120 minutes. Mean ± SEM are shown (n = 8 mice/group).